Synthesis of (14C)boceprevir, (13C3)boceprevir, and (D9.
Jules L. Dienstag, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015. Pharmacology. Boceprevir is metabolized primarily by aldoketoreductase to ketone-reduced metabolites but also by oxidative metabolism via CYP3A4, and its pharmacokinetic disposition is the same in normal subjects and in patients with HCV infection.Use boceprevir as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take boceprevir with food. Keep taking boceprevir as you have been told by your doctor or other health care provider, even if you feel well. It is important that you do not miss or skip a dose of boceprevir during treatment.Boceprevir (brand name Victrelis) is a new medication used to treat hepatitis C.It was approved in Europe in July 2011 for treatment of adults with genotype 1 chronic hepatitis C in combination with pegylated interferon and ribavirin.
Boceprevir is a man-made antiviral medication that targets hepatitis C virus ().Similar drugs include simeprevir and telaprevir ().These drugs are called direct-acting antiviral agents because they act directly on hepatitis C virus. They block the replication of hepatitis C virus in human cells by binding to and inhibiting protease enzymes that HCV use for reproducing.Efforts toward the synthesis and process optimization of boceprevir 1 are described. Boceprevir synthesis was optimized by telescoping the first three steps and last two steps of the five-step.
Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor. Ghosal A(1), Yuan Y, Tong W, Su AD, Gu C, Chowdhury SK, Kishnani NS, Alton KB.
